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Glutathione (GSH) has been shown in numerous studies to play an important role in mitochondrial ROS elimination (52, 53)

However, this molecule also reduces the radical forms of other antioxidants, such as tocopherol (Toc), enhancing the recycling capability [110]

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RMC tumor cells undergo distinct transcriptional reconfiguration by engaging interferon gamma receptor 1 (IFNGR1) signaling following combination ICT, leading to the activation of myeloid-affiliated transcriptional circuits mediated by the CEBPB / p300 complex that can promote cell proliferation, resulting in hyperprogression